CAS NO.146533-41-7 5-(4-Bromophenyl)-4,6-dichloropyrimidine

CAS NO.146533-41-7 5-(4-Bromophenyl)-4,6-dichloropyrimidine

About the CAS NO.146533-41-7 5-(4-Bromophenyl)-4,6-dichloropyrimidine : Macitentan is an endothelin receptor antagonist (ERA) approved for the treatment of pulmonary arterial hypertension (PAH). Macitentan blocks the ET1-dependent rise in intracellular calcium by inhibiting the binding of ET-1 to ET receptors. Blocking of the ETA receptor subtype seems to be of more importance in the treatment of PAH than blocking of ETB, likely because there are higher numbers of ETA receptors than ETB receptors in pulmonary arterial smooth muscle cells.
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Product Details

Product   name：

CAS NO.146533-41-7 5-(4-Bromophenyl)-4,6-dichloropyrimidine   

CAS   NO.:

146533-41-7

 


Structure：

146533-41-7.gif

 

 

Synonyms:

PyriMidine,   5-(4-broMophenyl)-4,6-dichloro-;5-(4-broMophenyl)-4,6-dichloropyriMidine;potassiuM   (N-propylsulfaMoyl)aMide;5-(4-Bromophenyl)-4,6-dichloro-1,3-diazine;4,6-Dichloro-5-(4-bromophenyl)pyrimidine;(4-broMophenyl)-4,6-dichloroPyriMidine;5-(4-Bromophenyl)-4,6-dichloro-Pyrimidin;5-(4-broMophenyl)-4

MF:

C10H5BrCl2N2

MW:

303.9701

Chemical   Properties:

White   powder

Purity

98%

Capacity:

1000KG   /month

Package

In   paper drums /Fluoride drums /plastic drums/IBC Tank ,etc.

Shipment   method :

By   Sea,Air,Courier door to door,etc.

Storeage:

Under   room temperature ,keep away from direct sun light

Loading   Port :

China   any port,Beijing,Shanghai,Hongkong

Transportation   condition:

Shipped   as non- dangerous chemicals

Application:

Halogenated   Hydrocarbons, organic fluoric, Nano electric material

 

About the CAS NO.146533-41-7 5-(4-Bromophenyl)-4,6-dichloropyrimidine  :

Macitentan is an endothelin receptor antagonist (ERA) approved for the treatment of pulmonary arterial hypertension (PAH).

Macitentan blocks the ET1-dependent rise in intracellular calcium by inhibiting the binding of ET-1 to ET receptors. Blocking of the ETA receptor subtype seems to be of more importance in the treatment of PAH than blocking of ETB, likely because there are higher numbers of ETA receptors than ETB receptors in pulmonary arterial smooth muscle cells.

 

Related chemical of CAS NO.146533-41-7 5-(4-Bromophenyl)-4,6-dichloropyrimidine  :

1.     PropylsulfaMide CAS NO.147962-41-2

2.       SulfaMide, N-propyl-,(potassiuM salt)(1:1) CAS NO.1393813-41-6

3.       N-Propylsulfuric diamide-sodium CAS NO.1642873-03-7


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